GrafikSNARE Database

Introduction to the SNARE database.
The SNARE Database is a collection of SNARE protein sequences classified by HMM profiles.
A detailed description of the SNARE protein classification can be found in:

Klöpper, T. H., Kienle, C. N., and Fasshauer, D.
An elaborate classification of SNARE proteins sheds light on the conservation of the eukaryotic endomembrane system
Molecular Biology of the Cell, Vol. 18, 3463–3471, September 2007 (PubMed / PDF)

Klöpper, T. H., Kienle, C. N., and Fasshauer, D.
SNAREing the basis of multicellularity: Consequences of protein family expansion during evolution
Molecular Biology and Evolution 2008; doi: 10.1093/molbev/msn151 (
PubMed / PDF)

Kienle, N., Klöpper, T. H., and Fasshauer, D.
Phylogeny of the SNARE vesicle fusion machinery yields insights into the conservation of the secretory pathway in fungi
BMC Evolutionary Biology 2009, 9:19 (
PubMed / PDF)

Kienle, N., Klöpper, T. H., and Fasshauer, D.
Differences in the SNARE evolution of fungi and metazoa
Biochemical Society Transactions (2009) Volume 37, part 4 (

In the SNAREs section of the database you have the possibility to view our classified sequences (SNAREs -> View DB) or to de novo classify protein sequences (SNAREs -> Find Motif). If you choose to view our classified sequences, you find additional information for each of the fields on the ViewDB site by clicking the question mark behind the field. If you choose to de novo classify protein sequences you may paste any protein sequence into the text field of the Find Motif site and hit the Submit-button. The results will be displayed shortly after.

More Information
For more information on the SNARE family you may visit our department homepage.
Additional information about Rab proteins are available at the Rab Database.
For an overview about AAA proteins, visit the AAA Database.

If you have any further questions or would like to submit additional sequences to the database please feel free to write an email.

Supplemental Information
Any supplemental information of publications can be downloaded from the Supplemental Data section of the above cited publication.
To view the Nexus files in the Supplemental Data section you may use SplitsTree

Build: 1.2